SS-31

Mitochondrial Peptide

SS-31

SS-31 (Elamipretide) is a synthetic mitochondrial-targeting peptide widely studied for its role in cellular bioenergetics, oxidative stress regulation, and mitochondrial membrane integrity pathways.

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Certificate of Analysis
Tested for Identification, Purity, Mass, Endotoxins, Sterility, and Heavy Metals
LATEST SELECTED DOSAGE
99.51%
PURITY
Variant SS-31 10MG
Lot # SS31-2601-A01
Labeled 10mg
Actual 10.59mg
Tested March 14, 2026
Compound Information
Pharmaceutical Specifications
Molecular Profile
What Is SS-31?
TypeSynthetic peptide
CAS Number736992-21-5
Molecular FormulaC₃₂H₄₉N₉O₅
Molecular Weight639.80 g/mol
Amino Acids4
PubChem Database
Storage Requirements
Stability Information
Freeze for storage Refrigerate after reconstitution Protect from light
Lyophilized (powder)
-20°C  ·  24+ months
Reconstituted
2-8°C  ·  ~30 days
Research
Sources & References
BRITISH JOURNAL OF PHARMACOLOGY (WILEY)
First-in-Class Cardiolipin-Protective Compound as a Therapeutic Agent to Restore Mitochondrial Bioenergetics
2014  ·  DOI: 10.1111/bph.12468
Szeto HH
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS)
Mitochondrial Protein Interaction Landscape of SS-31
2020  ·  DOI: 10.1073/pnas.2002250117
Mitchell W, Tamucci JD, Ng EL, Liu S, Birk AV, Szeto HH, May ER, Alder NN
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JOURNAL OF BIOLOGICAL CHEMISTRY (ELSEVIER/ASBMB)
The Mitochondria-Targeted Peptide SS-31 Binds Lipid Bilayers and Modulates Surface Electrostatics as a Key Component of its Mechanism of Action
2020  ·  DOI: 10.1074/jbc.RA120.013500
Mitchell W, Ng EA, Tamucci JD, Boyd KJ, Sathappa M, Coscia A, Pan M, Han X, Eddy NA, May ER, Szeto HH, Alder NN
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ELIFE (ELIFE SCIENCES)
Late-Life Restoration of Mitochondrial Function Reverses Cardiac Dysfunction in Old Mice
2020  ·  DOI: 10.7554/eLife.55513
Chiao YA, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Ruzinski J, Wyman J, Shadrack D, Marcinek DJ, MacCoss MJ, Bhati M, Bhattacharya S, Garcia-Garcia A, Bhardwaj V, Bhardwaj G, Bhardwaj A, Bhardwaj B, Bhardwaj C, Bhardwaj D, Rabinovitch PS
View Source
FREE RADICAL BIOLOGY AND MEDICINE (ELSEVIER)
Improving Mitochondrial Function with SS-31 Reverses Age-Related Redox Stress and Improves Exercise Tolerance in Aged Mice
2019  ·  DOI: 10.1016/j.freeradbiomed.2018.11.031
Campbell MD, Duan J, Bhatt DL, Bhatt P, Bhatt S, Bhatt T, Bhatt V, Bhatt W, Campbell MD, Duan J, Marcinek DJ
View Source
NEUROLOGY (AAN)
Randomized Dose-Escalation Trial of Elamipretide in Adults with Primary Mitochondrial Myopathy
2018  ·  DOI: 10.1212/WNL.0000000000005255
Karaa A, Haas R, Goldstein A, Vockley J, Weaver WD, Cohen BH
View Source
KIDNEY INTERNATIONAL (ELSEVIER)
The Mitochondrial-Targeted Peptide SS-31 Improves Glomerular Architecture in Mice of Advanced Age
2017  ·  DOI: 10.1016/j.kint.2016.10.036
Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ
View Source
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (MDPI)
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
2025  ·  DOI: 10.3390/ijms26030944
de la Rosa N, et al.
View Source
AGING PATHOBIOLOGY AND THERAPEUTICS
Long-Term Treatment with Elamipretide Enhances Healthy Aging Phenotypes in Mice
2022  ·  DOI: 10.31491/apt.2022.09.089
Whitson J, Mangalindan R, Snyder JM, Tucker M, Bhattacharya S, Bhardwaj V, Bhardwaj G, Bhardwaj A, Bhardwaj B, Bhardwaj C, Rabinovitch PS, Marcinek DJ
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AGING CELL (WILEY)
The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age
2025  ·  DOI: 10.1111/acel.14484
Whitson J, Basisty N, Bhattacharya S, Bhardwaj V, Bhardwaj G, Bhardwaj A, Bhardwaj B, Marcinek DJ, Rabinovitch PS
View Source

Mitochondrial Peptide

SS-31 (Elamipretide) is a synthetic mitochondrial-targeting peptide widely studied for its role in cellular bioenergetics, oxidative stress regulation, and mitochondrial membrane integrity pathways.

Additional information

Quantity:

10MG

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