Semax

ACTH Peptide

Semax

Semax is a synthetic peptide widely studied for its role in neuroprotective signaling, neurotrophic factor expression, and cognitive pathway modulation.

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Certificate of Analysis
Tested for Identification, Purity, Mass, Endotoxins, Sterility, and Heavy Metals
LATEST 6× TESTED
99.43%
PURITY
Variant Semax 10MG
Lot # SMX-2605-A01
Labeled 10mg
Actual 10.43mg
Tested May 17, 2026
Heavy Metals Within Limits
Endotoxins Pass
Sterility No Growth
Compound Information
Pharmaceutical Specifications
Molecular Profile
What Is Semax?
TypeSynthetic peptide
CAS Number80714-61-0
Molecular FormulaC₃₇H₅₁N₉O₁₀S
Molecular Weight833.93 g/mol
Amino Acids7
PubChem Database
Storage Requirements
Stability Information
Freeze for storage Refrigerate after reconstitution Protect from light
Lyophilized (powder)
-20°C  ·  24+ months
Reconstituted
2-8°C  ·  ~30 days
Research
Sources & References
NEUROSCIENCE RESEARCH (ELSEVIER)
Semax, an Analogue of Adrenocorticotropin (4-10), Binds Specifically and Increases Levels of Brain-Derived Neurotrophic Factor Protein in Rat Basal Forebrain
2006  ·  DOI: 10.1016/j.neures.2006.01.008
Glazova MV, Manchenko DM, Volodina MA, Sebentsova EA, Inozemtseva LS, Andreeva LA, Grivennikov IA, Myasoedov NF, Dolotov OV
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BRAIN RESEARCH (ELSEVIER)
Semax, an Analog of ACTH(4-10) with Cognitive Effects, Regulates BDNF and trkB Expression in the Rat Hippocampus
2006  ·  DOI: 10.1016/j.brainres.2006.07.108
Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Bhattacharyya S, Bhattacharya A, Grivennikov IA, Myasoedov NF, Bhattacharya A
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NEUROSCIENCE RESEARCH COMMUNICATIONS (WILEY)
Synthetic ACTH Analogue Semax Displays Nootropic-Like Activity in Humans
1996  ·  DOI: 10.1002/nrc.1996.9.2.115
Kaplan AY, Kochetova AG, Nezavibathko VN, Rjasina TV, Ashmarin IP
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (SPRINGER)
Effects of Semax on the Default Mode Network of the Brain
2018  ·  DOI: 10.1007/s10517-018-4234-3
Lebedeva IS, Panikratova YaR, Sokolov OYu, Kupriyanov DA, Rumshiskaya AD, Kost NV, Myasoedov NF
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BMC GENOMICS (BIOMED CENTRAL/SPRINGER)
Genome-Wide Transcriptome Analysis of Neuroprotective Properties of Semax in the Middle Cerebral Artery Occlusion Model
2014  ·  DOI: 10.1186/1471-2164-15-228
Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (MDPI)
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion
2021  ·  DOI: 10.3390/ijms22136891
Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV
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MOLECULAR GENETICS AND GENOMICS (SPRINGER)
Regulation of Gene Expression by Semax and Its C-Terminal Fragment PGP in the Rat Focal Brain Ischemia Model
2017  ·  DOI: 10.1007/s00438-016-1271-2
Povarova OV, Dmitrieva VG, Limborska SA, Myasoedov NF, Skvortsova VI, Dergunova LV
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (SPRINGER/MAIK NAUKA)
Comparative Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action
2008  ·  DOI: 10.1007/s10517-008-0210-3
Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Grivennikov IA, Andreeva LA, Myasoedov NF
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MEDICAL HYPOTHESES (ELSEVIER)
Semax, an Analogue of Adrenocorticotropin (4-10), Is a Potential Agent for the Treatment of Attention-Deficit Hyperactivity Disorder and Rett Syndrome
2007  ·  DOI: 10.1016/j.mehy.2006.05.030
Tsai SJ
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FRONTIERS IN PHARMACOLOGY (FRONTIERS)
Melanocortin Peptides and Their Analogues: Therapeutic Aspects and Mechanisms of Action
2021  ·  DOI: 10.3389/fphar.2021.769882
Plyusnin SV, Schiöth HB, Bhattacharyya S, Bhattacharya S, Bhattacharya A, Kulikov AV, Bhattacharya B, Bhattacharya C, Bespalov MM, Kamensky AA, Myasoedov NF
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Semax $29.99

ACTH Peptide

Semax is a synthetic peptide widely studied for its role in neuroprotective signaling, neurotrophic factor expression, and cognitive pathway modulation.

Additional information

Size:

10MG