MOTS-C

Metabolic Peptide

MOTS-C

MOTS-C is a mitochondrial-derived peptide widely studied for its role in cellular energy regulation and metabolic signaling pathways.

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Certificate of Analysis
Tested for Identification, Purity, Mass, Endotoxins, Sterility, and Heavy Metals
LATEST SELECTED DOSAGE
99.72%
PURITY
Variant MOTS-C 10MG
Lot # MOTSC-2601-A01
Labeled 10mg
Actual 11.27mg
Tested March 11, 2026
Compound Information
Pharmaceutical Specifications
Molecular Profile
What Is MOTS-C?
TypeSynthetic peptide
CAS Number1627580-64-6
Molecular FormulaC₁₀₁H₁₆₂N₂₈O₃₁S
Molecular Weight2,174.55 g/mol
Amino Acids16
PubChem Database
Storage Requirements
Stability Information
Freeze for storage Refrigerate after reconstitution Protect from light
Lyophilized (powder)
-20°C  ·  24+ months
Reconstituted
2-8°C  ·  ~30 days
Research
Sources & References
CELL METABOLISM (CELL PRESS)
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
2015  ·  DOI: 10.1016/j.cmet.2015.02.009
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
View Source
CELL METABOLISM (CELL PRESS)
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
2018  ·  DOI: 10.1016/j.cmet.2018.06.008
Kim KH, Son JM, Benayoun BA, Lee C
View Source
NATURE COMMUNICATIONS (SPRINGER NATURE)
MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
2021  ·  DOI: 10.1038/s41467-020-20790-0
Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C
View Source
CELL REPORTS (CELL PRESS)
Mitochondrial-Encoded MOTS-c Prevents Pancreatic Islet Destruction in Autoimmune Diabetes
2021  ·  DOI: 10.1016/j.celrep.2021.109447
Kong BS, Min SH, Lee C, Cho YM
View Source
JOURNAL OF TRANSLATIONAL MEDICINE (BIOMED CENTRAL/SPRINGER)
Mitochondria-Derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging
2023  ·  DOI: 10.1186/s12967-023-03885-2
Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J
View Source
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (MDPI)
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
2022  ·  DOI: 10.3390/ijms231911991
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC
View Source
FREE RADICAL BIOLOGY AND MEDICINE (ELSEVIER)
MOTS-c: A Novel Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism
2016  ·  DOI: 10.1016/j.freeradbiomed.2016.05.015
Kim SJ, Xiao J, Wan J, Cohen P, Yen K
View Source
AGING CELL (WILEY)
The Mitochondrial-Derived Peptide MOTS-c: A Player in Exceptional Longevity?
2015  ·  DOI: 10.1111/acel.12389
Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Sanchis-Gomar F
View Source
JOURNAL OF MOLECULAR MEDICINE (SPRINGER)
MOTS-c: An Equal Opportunity Insulin Sensitizer
2019  ·  DOI: 10.1007/s00109-019-01758-0
Kim SJ, Miller B, Kumagai H, Yen K, Cohen P
View Source
FRONTIERS IN ENDOCRINOLOGY (FRONTIERS)
Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects
2019  ·  DOI: 10.3389/fendo.2019.00331
Ramanjaneya M, Bettahi I, Jerobin J, Chandra P, Abi Khalil C, Skarulis M, Atkin SL, Abou-Samra AB
View Source

Metabolic Peptide

MOTS-C is a mitochondrial-derived peptide widely studied for its role in cellular energy regulation and metabolic signaling pathways.

Additional information

Quantity:

10MG

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