Melanotan I

Melanocortin Peptide

Melanotan I

Melanotan-1 (MT-1) is a synthetic peptide widely studied for its role in melanocortin receptor signaling, melanogenesis, and skin pigmentation modulation.

1
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Certificate of Analysis
Tested for Identification, Purity, Mass, Endotoxins, Sterility, and Heavy Metals
LATEST 6× TESTED
99.45%
PURITY
Variant Melanotan I 10MG
Lot # MT1-2606-A01
Labeled 10mg
Actual 11.25mg
Tested June 22, 2026
Heavy Metals Within Limits
Endotoxins Pass
Sterility No Growth
Compound Information
Pharmaceutical Specifications
Molecular Profile
What Is Melanotan I?
TypeSynthetic peptide
CAS Number75921-69-6
Molecular FormulaC₇₈H₁₁₁N₂₁O₁₉
Molecular Weight1,646.85 g/mol
Amino Acids13
PubChem Database
Storage Requirements
Stability Information
Freeze for storage Refrigerate after reconstitution Protect from light
Lyophilized (powder)
-20°C  ·  24+ months
Reconstituted
2-8°C  ·  ~30 days
Research
Sources & References
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (AMA)
Induction of Skin Tanning by Subcutaneous Administration of a Potent Synthetic Melanotropin
1991  ·  DOI: 10.1001/jama.266.19.2730
Levine N, Sheftel SN, Eytan T, Dorr RT, Hadley ME, Weinrach JC, Ertl GA, Toth K, McGee DL, Hruby VJ
View Source
NEW ENGLAND JOURNAL OF MEDICINE (NEJM/MMS)
Afamelanotide for Erythropoietic Protoporphyria
2015  ·  DOI: 10.1056/NEJMoa1411481
Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FP, Sijbrands EJ, de Rooij FW, Lebwohl M, Naik H, Goding CR, Wilson JH, Desnick RJ
View Source
BRITISH JOURNAL OF DERMATOLOGY (WILEY/BAD)
Long-Term Observational Study of Afamelanotide in 115 Patients with Erythropoietic Protoporphyria
2015  ·  DOI: 10.1111/bjd.13598
Biolcati G, Marchesini E, Sorge F, Barbieri L, Schneider-Yin X, Minder EI
View Source
JAMA DERMATOLOGY (AMA/JAMA NETWORK)
Afamelanotide and Narrowband UV-B Phototherapy for the Treatment of Vitiligo: A Randomized Multicenter Trial
2015  ·  DOI: 10.1001/jamadermatol.2014.1875
Lim HW, Grimes PE, Agbai O, Hamzavi I, Henderson M, Haddican M, Linkner RV, Lebwohl M
View Source
JAMA DERMATOLOGY (AMA/JAMA NETWORK)
Association of Afamelanotide with Improved Outcomes in Patients with Erythropoietic Protoporphyria in Clinical Practice
2020  ·  DOI: 10.1001/jamadermatol.2020.0352
Wensink D, Wagenmakers MAEM, Barman-Aksözen J, Friesema ECH, Wilson JHP, van Rosmalen J, Langendonk JG
View Source
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (TAYLOR & FRANCIS)
Afamelanotide for Prevention of Phototoxicity in Erythropoietic Protoporphyria
2021  ·  DOI: 10.1080/17512433.2021.1879638
Wensink D, Wagenmakers MAEM, Langendonk JG
View Source
LIFE (MDPI)
Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria
2023  ·  DOI: 10.3390/life13041066
Minder AE, Schneider-Yin X, Zulewski H, Minder CE, Minder EI
View Source
LIVER INTERNATIONAL (WILEY)
Erythropoietic Protoporphyrias: Pathogenesis, Diagnosis and Management
2024  ·  DOI: 10.1111/liv.16027
Minder AE, Kluijver LG, Barman-Aksözen J, Minder EI, Langendonk JG
View Source
BMC NEUROLOGY (BIOMED CENTRAL/SPRINGER)
A Feasibility and Safety Study of Afamelanotide in Acute Stroke Patients: An Open Label, Proof of Concept, Phase IIa Clinical Trial
2023  ·  DOI: 10.1186/s12883-023-03274-8
Kaelin U, Aellig K, Baker T, et al.
View Source
PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE (WILEY/ESPD)
EMA, It's Time to Reconsider! 10 Years Afamelanotide for Treating Erythropoietic Protoporphyria
2025  ·  DOI: 10.1111/phpp.70039
Falchetto S, et al.
View Source
Melanotan I $29.99

Melanocortin Peptide

Melanotan-1 (MT-1) is a synthetic peptide widely studied for its role in melanocortin receptor signaling, melanogenesis, and skin pigmentation modulation.

Additional information

Size:

10MG